Histomorphological responses to aqueous crude leaf extract of Alafia barteri on prefrontal cortex, heart, kidney, liver and testis of adult male Sprague-Dawley rats

  • Adelakun Sunday Aderemi Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, Nigeria
  • Babatunde Ogunlade Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, Ondo State, Nigeria
  • Olunsegun Dare Omotoso Department of Anatomy, Faculty of Basic Medical Sciences, Kogi State University Anyigba, Kogi State, Nigeria
Keywords: Alafia barteri, Frontal cortex, Heart, Kidney, Liver, Testis


Phytonutrients present in Alafia barteri leaves include antioxidants which serves to protect cells and tissues against detrimental effects of reactive oxygen species and other free radicals. This research work was targeted at investigating the activities of oral administration of aqueous leaf extract of Alafia barteri on the histology of the prefrontal cortex, heart, kidney, liver and testis of adult Sprague Dawley rats. Twelve (n=12) adult male Sprague Dawley rats weighing between 170-200 g (4-6 weeks old) were used for this study; they were divided into 2 groups of six rats each. The control group A received 2 ml/kg normal saline and treated group B received 500 mg/kg body weight aqueous extract of Alafia barteri for twenty eight days. The gross anatomical parameters of the selected organs and their histology were assessed. The gross anatomical and histological observation of the prefrontal cortex, heart, kidney, liver and testis revealed no visible distortion in Alafia barteri extract treated group when compared with control. Aqueous leaf extract of Alafia barteri thus has no deleterious effects on the histological profile of the prefrontal cortex, heart, kidney, liver and testis of the rats.

DOI: http://dx.doi.org/10.5281/zenodo.1284554


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How to Cite
Aderemi, A.; Ogunlade, B.; Omotoso, O. Histomorphological Responses to Aqueous Crude Leaf Extract of Alafia Barteri on Prefrontal Cortex, Heart, Kidney, Liver and Testis of Adult Male Sprague-Dawley Rats. European Journal of Biological Research 2018, 8, 105-111.
Research Articles