Synthesis of oxadiazole substituted new carbazole derivatives as antioxidant and antiurease agent

  • Nurhan Gümrükçüoğlu Karadeniz Technical University, Vocational School of Health Sciences, Department of Medical Services and Techniques, Trabzon, Turkey
  • Bahar Bilgin Sökmen Giresun University, Faculty of Arts and Sciences, Department of Chemistry, Giresun, Turkey
Keywords: Carbazole, Antioxidant activity, Radical scavenging activity, Antiurease activity

Abstract

Heterocyclic compounds containing nitrogen together with an oxygen atom in their structures are an important class of medicinal chemistry compounds due to their interesting diverse biological applications. Some compounds including carbazole ring, which are aromatic organic compounds in tricyclic structure, show biological activity in a wide spectrum. Oxadiazole compounds attract the attention of many chemists thanks to their antibacterial, antitumor, anticancer, anti-viral, antimicrobial, anti-HIV, antituberculosis and antioxidant properties. In this study, new oxadiazole substituted carbazole derivatives were synthesized and their antioxidant, antiurease activities were investigated. 9H-carbazole is a good starting material for the synthesis of carbazole derivatives. The antioxidant and antiurease activities of synthesized oxadiazole substituted new carbazole derivatives were investigated. Antioxidant activity methods such as DPPH (1,1’-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt) radical scavenging activities and iron reducing power capacities were used to determine antioxidant activity of the compounds. All synthesized carbazole compounds showed antioxidant and antiurease activity. While compound 4 shows the strongest enzyme inhibition activity, the least active compound was found 5. All tested compounds showed higher enzyme inhibition activity than thiourea. The highest and the lowest antioxidant activities were observed as compounds 3 and 6, respectively.

DOI: http://dx.doi.org/10.5281/zenodo.6612440

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References

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Published
2022-06-03
How to Cite
(1)
Gümrükçüoğlu, N.; Bilgin Sökmen, B. Synthesis of Oxadiazole Substituted New Carbazole Derivatives As Antioxidant and Antiurease Agent. European Journal of Biological Research 2022, 12, 181-189.
Section
Research Articles