Cucurbitaceae - the family that nourishes and heals

  • Stephen O. Fapohunda Department of Microbiology, Babcock University, Ilishan remo, Nigeria
  • Aderiike A. Adewumi Department of Basic Sciences, Babcock University, Ilishan remo, Nigeria
  • David O. Jegede Department of Basic Sciences, Babcock University, Ilishan remo, Nigeria
Keywords: Cucurbitaceae, Therapeutic, Nutritional, Extraction, Bioprospecting


A review of the activities of members of the Cucurbitaceae was carried out. Many of them are confirmed nutritious and therapeutical. Their global spread, diverse genera and phytochemical profile further confirm them as an attraction for the growth and survival of humanity. The need for alternative control measures to address resistance has heightened the passion for Cucurbitaceae in bioprospecting.



1. Jeffrey C. A new system of Cucurbitaceae. Botaniske Zhurnal. 2005; 90: 332-335.

2. Maynard D, Maynard DN. Cucumbers, melons and watermelons. In: Kiple KF, Ornelas KC, eds. The Cambridge world history of food. Cambridge: Cambridge University Press, 2000: 298-313.

3. Kocyan A, Zhang LB, Schaefer H, Renner SS. A multi-locus chloroplast phylogeny for the Cucurbitaceae and its implications for character evolution and classification. Mol Phylogenet Evol. 2007; 44: 553-557.

4. Rahman AHMM, Anisuzzaman M, Ferdous A, Rafiul IAKM, Naderuzzaman ATM. Study of nutritive value and medicinal uses of cultivated cucurbits. J Appl Sci Res. 2008; 4(5): 555-558.

5. Purseglove JW. Tropical crops. Dicotyledons. Vol. I. Longman, London, 1968.

6. Chakravarthy HL. Cucurbitaceae. Fascicles of flora of India. No. 11, Howrah, 1982.

7. Yamaguchi M. World vegetables. AVI, Westport. Conn, 1983.

8. Subrahmanyam NS. Modern plant taxonomy. Vikas Publishing House Pvt. Ltd. New Delhi, India, 2004: 316-321.

9. Mabberley DJ. Plant book - a portable dictionary of plants, their classification and uses. Cambridge University Press, 2008: 235.

10. Cobbley HCS, Leslie S, Steel WM. Introduction to the botany of tropical crops. 3rd edn, Longman Inc, New York, 1976.

11. Abou-Zaid MM, Lombardo DA, Kite GC, Grayer RJ, Veitch NC. Acylated flavone C-glycosides from Cucumis sativus. Phytochem. 2001; 58: 167-172.

12. Gill NS, Bali M. Evaluation of antioxidant, antiulcer activity of 9-β-methyl-19-norlanosta-5-ene type glycosides from Cucumis sativus seeds. Res J Med Plant. 2012; 6: 309-317.

13. Shweta SS, Priyanka T, Ganesh TG, Khadabadi SS. Distribution and ancient-recent medicinal uses of Trichosanthe species. Int J Phytopharm. 2012; 2(4): 91-97.

14. Todd CW, Maynard DN. Introduction to cucumber melons, and watermelon. 2003: 14-21.

15. Robyn JB. Plant diversity species accounts. Cucumis sativus Linnaeus. 2011: 1-5.

16. Dhiman K, Gupta A, Sharma DK, Gill NS, Goyal A. A review on the medicinally important plants of the family Cucurbitaceae. Asian J Clin Nutr. 2012; 4: 16-26.

17. Hasanuzzaman S, Islam MS, Sarwar S, Moghal MR, Ahmed JU, Islam MS. Preliminary antimicrobial activity and cytotoxicity of plant extracts (roots) of Coccinia grandis (Family: Cucurbitaceae). Int J Pharm Sci Res. 2013; 4(4): 1466-1468.

18. Gurudeeban S, Rajamanickam, Ramanathan T, Satyavani K. Antimicrobial activity of Citrullus colocynthis in Gulf of Mannar. Int J Curr Res. 2010; 2: 78-81.

19. Patel E, Murthy KR. A review on potency of some Cucurbitaceae plants against hepatitis and antimicrobial activities. Ind J Fund Appl Life Sci. 2013; 3(2): 13-18.

20. Adebooye OC. Phyto-constituents and anti-oxidants activity of the pulp of snake tomato (Trichosanthes cucumerina L.). Afr J Trad Compl Alt Med. 2008; 5: 173-179.

21. Garau C, Cummings E, Phoenix D A, Singh J. Beneficial effects and mechanism of action of Momordica charantia in the treatment of diabetes mellitus: a mini review. Int J Diabet Metab. 2003; 11: 46-55.

22. Kumar D, Kumar S, Singh J, Narender R, Vashistha BD, Singh N. Free radical scavenging and analgesic activities of Cucumis sativus L. fruit extract. J Young Pharm. 2010; 2(4): 365-368.

23. Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharm. 2003; 84: 105-108.

24. Ramalingam B, Patel CN. Studies on anthelmintic and antimicrobial activity of the leaf extracts of Lagenaria siceraria. J Glob Pharm Technol. 2010; 2: 66-70.

25. Das J, Anusua C, Subrata KB, Utpal KK, Syeda RS, Sheikh ZR, Md Abdul M. Cytotoxicity and antifungal activities of ethanolic and chloroform extracts of Cucumis sativus Linn (Cucurbitaceae) leaves and stems. Res J Phytochem. 2012; 6: 25-30.

26. Santos KKA, Edinardo FF, Matias CE, Sobral-Souza SR, Tintino MFB, Morais-Braga G, Guedes MM. Trypanocide, cytotoxic, and antifungal activities of Momordica charantia. Pharm Biol. 2012; 50(2): 162-166.

27. Wang S, Zheng Y, Xiang F, Li S, Yang G. Antifungal activity of Momordica charantia seed extracts toward the pathogenic fungus Fusarium solani L. J Food Drug Anal. 2016; 24(4): 881-887.

28. Bulbul IJ. Determination of antibacterial and antifungal and cytotoxic activities of n hexane, chloroform and ethyl acetate extracts of M. charantia leaves. Pharma Tutor. 2016; 4(3): 28-33.

29. Tang J, Xiangjie M, Hao L, Zhao J, Zhou L, Qiu M, et al. Antimicrobial activity of sphingolipids isolated from the stems of cucumber (Cucumis sativus L.). Molecules. 2010; 15: 9288-9297.

30. Deshpande JR, Choudhari AA, Mishra MR, Meghre VS, Wadodkar SG, Dorle AK. Beneficial effects of Lagenaria siceraria (Mol.) Standley fruit epicarp in animal models. Indian J Exp Biol. 2008; 46: 234-242.

31. Shehata AZI. Studies on the efficacy of some plant extracts against the mosquito vector, Culex pipiens (Diptera: Culicidae). Unpublished M. Sc. Thesis, Fac. Sci., Al-Azhar Univ., Egypt, 2010.

32. Ghule B, Ghante MH, Yeole, PG, Saoji AN. Diuretic activity of Lagenaria siceraria fruit extracts in rats. Ind J Pharma Sci. 2007; 69: 817-819.

33. Gonzalez FG, Di-Stasi LC. Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice. Phytomed. 2002; 9: 125-134.

34. Santhasheela P, Renuka D, Kaleeswari P, Ramya A, Saritha M. In vitro antimicrobial screening and phytochemical profile of Cucurbitaceae leaves extracts. BioTechnol Ind J. 2011; 1: 56-60.

35. Gurudeeban S, Rajamanickam E, Ramanathan T, Satyavani K. Antimicrobial activity of Citrullus colocynthis in Gulf of Mannar. Int J Curr Res. 2010; 2: 78-81.

36. Abdullah N, Syida WS, Kamarudin W, Samicho Z, Aziman N, Zulkifli KS. Evaluation of in-vitro antioxidant and antimicrobial activities of the various parts of Benincasa hispida. Int J Pharm Tech Res. 2012; 4(4): 1367-1376.

37. Warrier PK, Nambiar VPK, Ramakutty C. Indian medicinal plants. Orient Longman Limited, India, 1994: 261.

38. Costa JGM, Nascimento EMM, Campos AR, Rodrigues, FFG. Antibacterial activity of Momordica charantia (Curcubitaceae) extracts and fractions. J Basic Clin Pharm. 2010; 2(1): 45-49.

39. Osuagwu GGE, Ejikeme FO. The antimicrobial activity of the leaves of some wild Cucurbitaceae species from South East Nigeria. Int J Pharm Pharmaceut Res. 2005; 2(4): 42-52.

40. Nithiya P, Mohan K. Antioxidative effect of Trichosanthes tricuspidata root extract on sildenafil induced migraine in albino mice. Pharma Res. 2009; 1: 402-405.

41. Rakholiya K, Vaghela P, Rathod, Chanda S. Comparative study of hydroalcoholic extracts of Momordica charantia L. against foodborne pathogens. Indian J Pharm Sci. 2014; 76(2): 148-156.

42. Hernández JEB, León J. Neglected crops 1492 from a different perspective. FAO (FAO Plant Production and Protection Series, no.26), 1994.

43. Achi M, Fokou E, Tchiegang C, Fotso M, Mbiapo F. Nutritive value of some Cucurbitaceae oil seeds from different regions of Cameroon. Afr J Biotech. 2005: 4(11): 1329-1334.

44. Lazos E. Nutritional, fatty acid, and oil characteristics of pumpkin and melon seeds. J Food Sci. 1986; 51(5): 1382-1383.

45. Paris HS. Multiple allelism at the D locus in squash. J Hered. 1996; 87: 391-395.

46. Winkler C, Wirleitner B, Schennach, Schroecksnadel K, Fuchs D. Extracts of pumpkin seeds suppress stimulated peripheral blood mononuclear cells in vitro. Am J Immunol. 2005; 1(1): 6-11.

47. Abdel-Rahman, Manal K. Effect of pumpkin seed (Cucurbita pepo L.) diets on benign prostatic hyperplasia (BPH): chemical and morphometric evaluation in rats. World J Chem. 2006; 1(1): 33-40.

48. Marzouk, BZ, Marzouk E, Haloui N, Fenina A, Bouraoui, Aouni M. Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from Southern Tunisia. J Ethnopharmacol. 2010; 128: 15-19.

49. Gill NS, Kaur S, Arora R, Bali M. Screening of antioxidant and antiulcer potential of Citrullus colocynthis methanolic seed extract. Res J Phytochem. 2011; 2: 98-106.

50. Kumar S, Kumar D, Jusha M, Saroha K, Singh N, Vashishta B. Antioxidant and free radical scavenging potential of Citrullus colocynthis (L.) Schrad. methanolic fruit extract. Acta Pharmaceut. 2008; 58: 215-220.

51. Dash P, Ghosh G. Amino acid profiling and antimicrobial activity of Cucurbita moschata and Lagenaria siceraria seed protein hydrolysates. Nat Prod Res. 2018; 32(17): 2050-2053.

52. Satheesh SL, Murugan K. Antimicrobial activity of protease inhibitor from leaves of Coccinia grandis (L.) Voigt. Ind J Exp Biol. 2011; 49: 366-374.

53. Puri M, Kaur I, Kanwar RK, Gupta RC, Chauhan A, Kanwar JR. Ribosome inactivating proteins (RIPs) from Momordica charantia for anti-viral therapy. Curr Mol Med. 2009; 9: 1080-1086.

54. Wang F, Song H; Wang X, Zhang W, Wang B, Zhao J, Hu Z. Tandem multimer expression and preparation of hypoglycemic peptide MC6 from Momordica charantia in Escherichia coli. Appl Biochem Biotechnol. 2012; 166(3): 612-619.

55. Gurudeeban S, Ramanathan T, Satyavani K. Characterization of volatile compounds from bitter apple Citrullus colocynthis using GC-MS. Int J Chem Analyt Sci. 2011: 2(8): 108-110.

56. Eseyin OA, Sattar MA, Rathore HA. A review of the pharmacological and biological activities of the aerial parts of Telfairia occidentalis Hook.f. (Cucurbitaceae). Trop J Pharm Res. 2001; 13(10): 1761-1769.

57. Udoh, P, Ojenikoh C, Udoh V. Antifertility effect of Momordica charantia (bitter gourd) fruit on the gonads on male guinea pigs. Global J Pure Appl Sci. 2001; 7: 627-631.

58. Ahmed B, Alam T, Khan SA. Hepatoprotective activity of Luffa echinata fruits. J Ethnopharmacol. 2001; 76: 187-189.

59. Akihisa T, Tokuda H, Ichiishi E, Mukainaka T, Toriumi M. Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines. Cancer Lett. 2001; 173: 9-14.

60. Acosta-Patino JL, Jimenez-Balderas E, Juarez-Oropeza MA, Diaz-Zagoya JC. Hypoglycemic action of Cucurbita ficifolia on type 2 diabetic patients with moderately high blood glucose levels. J Ethnopharmacol. 2001; 77: 99-101.

61. Poovendran P, Vidhya N, Murugan S. Antimicrobial activity of Coccinia grandis against biofilm and ESBL producing uropathogenic E. coli. Global J Pharmacol. 2011; 5(1): 23-26.

62. Shagal MH, Kubmarawa D. Antimicrobial and phytochemical screening of Icacina trichantha. Am J Biomed Life Sci. 2013; 1(2): 37-40.

63. Fidrianny LI, Darmawati A, Sukrasn O. Antioxidant capacities from different polarities extracts of Cucurbitaceae leaves using frap, dpph assays and correlation with phenolic, flavonoid, carotenoid content. Int J Pharm Pharmaceut Sci. 2010; 6(2): 857-862.

64. Amira K, Aminah A, Zuhair A. Evaluation of bitter melon Momordica charantia extract administration in the antioxidant and free radical scavenging activities in plasma and liver in male rats. Int Food Res J. 2013; 20: 319.

65. Nobre CP, Raffin FN, Moura TF. Standardization of extracts from Momordica charantia L.(Cucurbitaceae) by total flavonoids content determination. Acta Farm Bonaerense. 2005; 24(4): 562-566.

66. Abdel Karim M, Balsam O, Inas O. GC-MS analysis and antimicrobial activity of Sudanese Cucurbita pepo (Cucurbitaceae) fixed oil. World J Pharm Life Sci. 2016; 2(6): 492-502.

67. Vora JD, Rane L, Kumar SA. Biochemical, anti-microbial and organoleptic studies of cucumber (Cucumis sativus). Int J Sci Res. 2014; 3(3): 661-664.

68. Abbassi F, Ayari B, Mhamdi B, Toumi L. Phenolic contents and antimicrobial activity of squirting cucumber (Ecballium elaterium) extracts against food-borne pathogens. Pak J Pharm Sci. 2014; 27(3): 475-479.

69. Yadav S, Tomar AK, Yadav RN. Screening of antifungal proteins from plants of Cucurbitaceae family against Fusarium oxysporum: potential as biofungicides. Int Res J Environ Sci. 2013; 2(6): 91-96.

70. Ibrahim MA, Saeed BO, Elsaid Konozy EH, Ahmed SM, Mohamed ME. Isolation and purification of lection from Momordica balsamina seeds. Am Int J Contem Res.2 014; 4(5): 131-136.

71. Meena MC, Patni V. Isolation and identification of flavonoid quercetin from Citrullus colocynthis (Linn.) Schrad. Asian J Exp Sci. 2008; 22(1): 137-142.

72. Zulbadli N, Alwi H, Ku-Hamid KH. Momordica charantia extraction by using pressurized boiling system and compounds identification through gas chromatography mass spectrometry. Int J Eng Technol. 2011; 11(3): 79-84.

73. Martínez M, Betancourt J, Alonso-González N, Jauregui A. Screening of some Cuban medicinal plants for antimicrobial activity. J Ethnopharm. 1996; 52(3): 171-174.

74. Rajasree RS, Sibi P, Femi F, Helen W. Phytochemicals of Cucurbitaceae family - a review. Int J Pharm Phyt Res. 2016; 8(1): 113-123.

75. Lima AP, Barbosa CES, Pereira FC, Vilanova-Costa ACT, Ribeiro ASB, Silva HD, et al. Siolmatra brasiliensis (Cogn.) Baill., Cucurbitaceae, acute toxicity in mice. Rev Brasil Farmacog. 2010; 20(6): 917-921.

76. Chukwuma EC, Soladoye MO, Feyisola RT.Traditional medicine and the future of medicinal Plants in Nigeria. J Med Plant Stud. 2015; 3(4): 23-29.

77. Nee M, Schaefer H, Renner SS. The relationship between Anisosperma and Fevillea (Cucurbitaceae), and a new species of Fevillea from Bolivia. System Bot. 2009; 34(4): 704-708.

78. Campbell RN, Wipf-Scheibel C, Lecoq H. Vector-assisted seed transmission of melon necrotic spot virus in melons. Phytopathol. 1996; 86: 1294-1298.
How to Cite
Fapohunda, S., Adewumi, A., & Jegede, D. (2018). Cucurbitaceae - the family that nourishes and heals. MicroMedicine, 6(2), 85-93. Retrieved from
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