Zika and SARS-CoV-2: neuroinflammation and neurodegenerative outcomes

  • Jenniffer Ramos Martins Laboratory of Cell Biology, Department of Biological Sciences, State University of Minas Gerais, Ibirité, MG, Brazil
  • Felipe Emanuel Oliveira Rocha Laboratory of Cell Biology, Department of Biological Sciences, State University of Minas Gerais, Ibirité, MG, Brazil
  • Vivian Vasconcelos Costa, Costa Center of Research and Drug Development, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil https://orcid.org/0000-0002-0175-642X
  • Felipe Ferraz Dias, Dias Laboratory of Cell Biology, Department of Biological Sciences, State University of Minas Gerais, Ibirité, MG, Brazil https://orcid.org/0000-0002-3493-6929
Keywords: COVID-19, Infection, Inflammation, Neurodegeneration, SARS-CoV-2, Zika virus


Through the emergence of new viral infectious diseases, epidemics and pandemics have brought great impacts on public health in recent decades. In this review, we sought to understand the association between the neurological outcomes of two relevant infectious diseases, Zika and COVID-19. Zika can trigger neurological and ophthalmic damage in children born from infected mothers, as well as, Guillain-Barré syndrome, encephalitis, and myelitis in adults. On the other hand, the SARS-CoV-2 virus has great potential to trigger an inflammatory process in the optic nerve, with optic neuritis as the most reported pathology. Although Zika and SARS-CoV-2 infections are associated with different clinical manifestations, both may trigger similar pathogenic processes, through the induction of pro-inflammatory chemokines and cytokines release, triggering neurological and ophthalmological damage in infected patients. Elements in common have been found in both infections, such as antibodies against myelin oligodendrocyte glycoprotein, and the production of CXCL10, a chemokine responsible for the activation of several cellular types (T cells, eosinophils, monocytes and NK cells) in which are responsible to the induction of a cytokine cascade in the body. Based on these last findings, we suggest that both infections have similar activation characteristics as well as common pathogenic mechanisms associated with central nervous system involvement.

DOI: http://dx.doi.org/10.5281/zenodo.7374340


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How to Cite
Martins, J.; Rocha, F.; Costa, V.; Dias, F. Zika and SARS-CoV-2: Neuroinflammation and Neurodegenerative Outcomes. European Journal of Biological Research 2022, 12, 307-319.
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