Occurrence and characteristics of the migrating myoelectric complex in ovine gallbladder and its relationships to the small intestinal motility

Krzysztof W. Romański

Abstract


An attempt has been made to identify the migrating motility complex in the ovine gallbladder and to span it with the small-intestinal pattern. For this purpose, four rams underwent surgical implantation of bipolar electrodes into the abomasal antrum, entire small bowel and gallbladder infundibulum, corpus and fundus. The strain gauge force transducer was also mounted in the gallbladder fundus, near the electrode. In the course of chronic experiments, the myoelectrical and motor activity was recorded in fasted and non-fasted rams, with or without feeding. Cyclic myoelectrical and motor activity pattern was found in the gallbladder. It resembled the migrating myoelectric complex present in the small bowel. The gallbladder pattern was well correlated with the intestinal migrating complex. Three or four phases of this pattern could be identified in all gallbladder regions. The most characteristic phase 3-like activity was longer and more intense in the gallbladder fundus as compared with the upper gallbladder regions. In both the small bowel and gallbladder, motility alterations caused by various feeding conditions were comparable. Therefore, the migrating motility complex occurs in the ovine gallbladder, albeit its putative role can be different from that in the small bowel, at least in part.

Keywords


Sheep; Gallbladder; Myoelectrical activity; Mechanical activity; Migrating motility complex

Full Text:

PDF

References


Grace PA, Poston GJ, Williamson RCN. Biliary motility. Gut. 1990; 31: 571-582.

Shaffer EA. Review article: control of gall-bladder motor function. Aliment Pharmacol Ther. 2000; 14(suppl 2): 2-8.

Jazrawi RP. Review article: measurement of gall-bladder motor function in health and disease. Aliment Pharmacol Ther. 2000; 14(suppl. 2): 27-31.

Niebergall-Roth E, Teyssen S, Singer MV. Neurohormonal control of gallbladder motility. Scand J Gastroenterol. 1997; 32(8): 737-750.

Ruckebusch Y. Gastrointestinal motor function in ruminants. In: Schultz SG, section ed. Handbook of physiology. The gastrointestinal system I. Bethesda, American Physiological Society, 1989: 1225-1282.

Romański KW. Feeding versus cholecystokinin - spectrum of actions on ovine gallbladder contractility assessed with real-time ultrasonography. Wien Tierärztl Mschr. 2004; 91(9): 226-235.

Bueno L, Praddaude F. Electrical activity of the gallbladder and biliary tract in sheep and its relationships with antral and duodenal motility. Ann Biol Anim Bioch Biophys. 1979; 19: 1109-1121.

Romański KW. Characteristics and cholinergic control of the ‘minute rhythm’ in ovine antrum, small bowel and gallbladder. J Vet Med. 2002; 49(6): 313-320.

Kaji T, Takamatsu H, Kojiya H. Motility of the gastrointestinal tract and gallbladder during long-term total parenteral nutrition in dogs. J Parent Enteral Nutr. 2002; 26: 198-204.

Romański KW. The myoelectric (M) patterns in ovine gallbladder (GB). J Physiol Pharmacol. 1996; 47(suppl. 2): 102.

Romański KW. The rebound excitation triggered by anticholinergic drugs from ovine pyloric antrum, small bowel and gallbladder. J Physiol Pharmacol. 2003; 54(1): 121-133.

Romański KW. The effect of cholecystokinin-octapeptide and cerulein on phasic and tonic components in ovine duodenum with special reference to the ‘Minute Rhythm’. Acta Vet Brno. 2007; 76(1): 14-25.

Snedecor, GW, Cochran WG. Statistical methods. 6th edn. Ames, The Iowa State University Press, 1971.

Ruckebusch Y, Soldani G. Gallbladder motility in sheep: effects of cholecystokinin and related peptides. J Vet Pharmacol Ther. 1985; 8(3): 263-269.

Romański KW. Ovine model for clear-cut study on the role of cholecystokinin in antral, small intestinal and gallbladder motility. Pol J Pharmacol. 2004; 56(2): 247-256.

Itoh Z, Takahashi I, Nakaya M, Suzuki T, Arai H, Wakabayashi K. Interdigestive gallbladder bile concentration in relation to periodic contraction of gallbladder in the dog. Gastroenterology. 1982; 83(4): 645-651.

Takahashi I, Kern MK, Dodds WJ, Hogan WJ, Sarna SK, Soergel KH, Itoh Z. Contraction pattern of opossum gallbladder during fasting and after feeding. Am J Physiol. 1986; 250(2 Pt 1): G227-G235.

Scott RB, Diamant SC. Biliary motility associated with gallbladder storage and duodenal delivery of canine hepatic biliary output. Gastroenterology. 1988; 95(6): 1069-1080.

Stolk MF, van Erpecum KJ, Smout AJ, Akkermans LM, Jansen JB, Lamers CB, et al. Motor cycles with phase III in antrum are associated with high motilin levels and prolonged gallbladder emptying. Am J Physiol. 1993; 264(4 Pt 1): G596-G600.

Hasler WL. Small intestinal motility. In: Johnson LR, ed. Physiology of the gastrointestinal tract. Amsterdam, Elsevier, Amsterdam, 2006: 935-964.

Sarna SK. Cyclic motor activity; migrating motor complex: 1985. Gastroenterology. 1985; 89(4): 894-913.

Sarna SK. Myoelectrical and contractile activities of the gastrointestinal tract. In: Schuster MM, Crowell MD, Koch KL, eds. Schuster atlas of gastrointestinal motility in health and disease. Hamilton, BC Decker, Inc, 2002: 1-18.

Ludwick JR, Bass P. Contractile and electric activity of the extrahepatic biliry tract and duodenum. Surg Gynecol Obst. 1967; 124: 536-546.

Matsumoto T, Sarna SK, Condon RE. Gallbladder electrical activity in vivo. Gastroenterology. 1985; 88: 1493.

Laplace JP. L’excretion biliaire chez le Porc. 1) Électromyographie des voies biliaires extrahépatiques. Rec Méd Vét. 1976; 152: 33-43.

Fioramonti J, Ruckebusch Y. Diet and caecal motility in sheep. Ann Rech Vét. 1971; 10: 593-599.

Ryan JP. Motility of the gallbladder and biliary tree. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York, Raven Press, 1987: 695-721.

Tierney S, Pitt HA, Lillemoe KD. Physiology and pathophysiology of gallbladder motility. Surg Clin North Am. 1993; 73(6): 1267-1290.


Refbacks

  • There are currently no refbacks.