Evaluation of antiplasmodial effects of the ethanolic leaf extract of Salacia lehmbachii on Plasmodium berghei infected mice

Augustine Dick Essien, Grace Akanimo Essiet, Godwin Christian Akuodor, Nwobodo Ndubuisi Nwobodo, Joseph Linus Akpan, Simon John Utsalo

Abstract


Salacia lehmbachii leaves are used in Nigerian traditional medicine for the treatment of malaria and other diseases. The ethanolic extract was tested for its activities against suppressive, prophylactic and established infections in Plasmodium berghei infected albino mice at dose levels of 100, 200 and 400 mg/kg; while chloroquine (10 mg/kg) was used as positive control. The extract exhibited significant dose-related antiplasmodial activities on parasites with the used-dose levels, showing significant mean survival time. The results, therefore, co-relate with claims by traditional users for the treatment of malaria and other feverish conditions; and could serve as source of potential new antimalarial agents.


Keywords


Malaria; Salacia lehmbachii; Mice; Suppressive; Prophylactic; Curative

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References


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