Total phenol and flavonoid content, antioxidant and cytotoxicity assessment of Algerian Launaea glomerata (Cass.) Hook.f. extracts

  • Imane Chelalba VTRS Laboratory, Chemistry Department, University of Hamma Lakhdar El-Oued, P.O. Box, 789, 39000, Algeria
  • Abdelkrim Rebiai Chemistry Department, University of Hamma Lakhdar El-Oued, P.O. Box, 789, 39000, Algeria
  • Hanane Debbeche VTRS Laboratory, Chemistry Department, University of Hamma Lakhdar El-Oued, P.O. Box, 789, 39000, Algeria
  • Samir Begaa Reactor Chemistry Department, Nuclear Research Centre of Birine, P.O.Box 180, Ain Oussera, 17200 Djelfa, Algeria
  • Mohammed Messaoudi Chemistry Department, University of Hamma Lakhdar El-Oued, P.O. Box, 789, 39000, Algeria; Reactor Chemistry Department, Nuclear Research Centre of Birine, P.O.Box 180, Ain Oussera, 17200 Djelfa, Algeria
  • Naima Benchikha Chemistry Department, University of Hamma Lakhdar El-Oued, P.O. Box, 789, 39000, Algeria
Keywords: Launaea glomerata, Medicinal plant, Antioxidant activity, Antitumor, Phenols, Flavonoids


El-Oued province (southeast Algeria), is located in a medicinal plant-rich area; Launaea glomerata (Cass.) Hook. f. is one among them which is a perennial herb spread widely in the arid regions of the Mediterranean Sea. The selection of the studied plant corresponds perfectly to the scientific needs due two reasons, firstly because these samples are used by the Algerian population as herbal remedies for primary health care, secondly, for the lack of published data on it. The aim of this investigation is to provide new data on quantities of phenols, which were estimated at 25.81 mg GAE/g extract and flavonoids (49.13 mg RE/g extract), and the determination of antioxidant activities by three ways (DPPH, CAT, ABTS), the results of IC50 equals to 98.07 mg TE/g extract for DPPH• and 286.5 mg eq. AG/g for ABTS assays, noted that the best inhibition was by the ABTS root. We also conducted a test for the inhibitory ability of extract against cancer cells tested on both human hepatocellular carcinoma (HePG2) and colon cells (HCT116), the results were negative. The data obtained in this work can be useful for the pharmaceutical industry, also used in the Algerian medicinal herbs database.



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How to Cite
Chelalba, I.; Rebiai, A.; Debbeche, H.; Begaa, S.; Messaoudi, M.; Benchikha, N. Total Phenol and Flavonoid Content, Antioxidant and Cytotoxicity Assessment of Algerian Launaea Glomerata (Cass.) Hook.f. Extracts. European Journal of Biological Research 2021, 11, 168-176.
Research Articles